Photoswitchable precision glycooligomers and their lectin binding

• Daniela Ponader,
• Sinaida Igde,
• Marko Wehle,
• Katharina Märker,
• Mark Santer,
• David Bléger and
• Laura Hartmann

Beilstein J. Org. Chem. 2014, 10, 1603–1612, doi:10.3762/bjoc.10.166

• could previously also show for glycooligomers binding to Concanavalin A (Con A) lectin receptor [7][10][11]. All multivalent glycooligomers show a decrease in IC50, i.e., an increase in binding affinity in comparison to the monovalent β-methyl galactoside. Overall, IC50 values are in the µM range, with

New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin

• Otman Otman,
• Paul Boullanger,
• Eric Drockenmuller and
• Thierry Hamaide

Beilstein J. Org. Chem. 2010, 6, No. 58, doi:10.3762/bjoc.6.58

• . Keywords: click chemistry; con A lectin; dynamic light scattering; glycopolymer; polymer nanoparticles; Introduction Over the last decades, research efforts in pharmaceutical, food and cosmetics technologies have been directed not only towards the syntheses of new bioactive entities or medicines, but also

• polymer surfactants for the colloidal stabilization of polycaprolactone (PCL) nanoparticles. Preliminary studies towards the recognition of these glyco-nanoparticles by specific concanavalin A (con A) lectin have been carried out, which provided clear evidence for the presence of carbohydrate units on the